An effective synthesis of 5,4'-disubstituted flavones via a cesium enolate assisted intramolecular ipso-substitution reaction.
نویسندگان
چکیده
A variety of 5,4'-disubstituted flavones, which are anticipated to be androgen receptor antagonists to treat diseases mediated by the androgen receptor, were synthesized. It was found that an intramolecular ipso-substitution reaction via cesium enolate using 2-fluoro-6-hydroxyacetophenone and various benzoyl chlorides was effective in the preparation of 5-hydroxy-4'-alkylflavones.
منابع مشابه
A highly enantio- and diastereoselective catalytic intramolecular Stetter reaction.
A highly enantio- and diastereoselective intramolecular Stetter reaction has been developed. Subjection of alpha,alpha-disubstituted Michael acceptors to an asymmetric intramolecular Stetter reaction results in a highly enantioselective conjugate addition and a diastereoselective proton transfer. Available evidence suggests the diastereoselective protonation occurs via intramolecular delivery t...
متن کاملSBA-15-supported-dithizone-copper(I): An efficient heterogeneous catalyst for synthesis of 1,4-disubstituted 1,2,3-triazoles in water
In this work, the SBA-15-supported dithizone-copper(I) [SBA-15-dtz–Cu(I)] complex as a new heterogeneous catalyst is prepared for the first time. The catalyst prepared is characterized by the FT-IR spectroscopy, SEM, and ICP techniques. This reusable heterogeneous catalyst can be used in the click reactions for the green and facile synthesis of 1,4-disubstituted 1,2,3-triazolesvia a on...
متن کاملNatural kaolin as an efficient recyclable catalyst for the synthesis of new 2,4-disubstituted quinolines
Substituted 2, 4- diphenyl quinolines were synthesized by a multicomponent domino reaction of anilines, aldehydes and terminal aryl alkynes. The synthetic pathway involves the formation of an imine, followed by the intermolecular addition of an alkyne to the imine. This intermediate immediately undergoes ring closure and oxidative aromatization. The reaction is catalyzed by natural kaolin, a st...
متن کاملPreparation of Nickel Nanoparticles by Intramolecular Reaction of Nickel(II) Hydrazine Complex in the Solid State at Room Temperature
Ni6(N2H4)6(SO4)4(OH)2(H2O)8](SO4)(H2O)10 complex was prepared according to literature report. The reaction between aforementioned complex via sodium alkoxides as a reactants, were carried out in the solid state. The [Ni6(N2H4)6(SO4)4(OH)2(H2O)8](SO4)(H2O)10 undergoes an intramolecular two electrons oxidation-reduction reaction at room temperature and metallic nickel nanoparticles (Ni1-Ni5) was ...
متن کاملNatural kaolin as an efficient recyclable catalyst for the synthesis of new 2,4-disubstituted quinolines
Substituted 2, 4- diphenyl quinolines were synthesized by a multicomponent domino reaction of anilines, aldehydes and terminal aryl alkynes. The synthetic pathway involves the formation of an imine, followed by the intermolecular addition of an alkyne to the imine. This intermediate immediately undergoes ring closure and oxidative aromatization. The reaction is catalyzed by natural kaolin, a st...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Chemical & pharmaceutical bulletin
دوره 58 8 شماره
صفحات -
تاریخ انتشار 2010